Autor:

Bossaller; C.; Auch-Schwelk, W.; Graf, K.; Grafe, M.; Catadelgirmen, G.; Ennker, J.; Fleck, E.

Erscheinungsort:

J Cardiovasc Pharmacol 1992;20 Suppl 3:S13-6

Inhalt:

Three agents with K(+)-channel-opening activity-nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 » nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 » nicorandil in human arteria mammaria. These data demonstrate that K(+)-channel openers are effective vasorelaxant agents in human coronary artery and human arteria mammaria. Bimakalim and EMD 56431 were more potent than nicorandil, a drug that also activates guanylate cyclase.